Fitness
Effect of esketamine combined with dexmedetomidine on delirium in sedation for mechanically ventilated ICU patients: protocol for a nested substudy within a randomized controlled trial – Trials
Wilson JE, Mart MF, Cunningham C, Shehabi Y, Girard TD, MacLullich AMJ, et al. Delirium. Nat Rev Dis Primers. 2020;6(1):90. https://doi.org/10.1038/s41572-020-00223-4.
Jayaswal AK, Sampath H, Soohinda G, Dutta S. Delirium in medical intensive care units: incidence, subtypes, risk factors, and outcome. Indian J Psychiatry. 2019;61(4):352–8. https://doi.org/10.4103/psychiatry.IndianJPsychiatry_583_18.
Pandharipande P, Cotton BA, Shintani A, Thompson J, Pun BT, Morris JA Jr, et al. Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma. 2008;65(1):34–41. https://doi.org/10.1097/TA.0b013e31814b2c4d.
Chaiwat O, Chanidnuan M, Pancharoen W, Vijitmala K, Danpornprasert P, Toadithep P, et al. Postoperative delirium in critically ill surgical patients: incidence, risk factors, and predictive scores. BMC Anesthesiol. 2019;19(1):39. https://doi.org/10.1186/s12871-019-0694-x.
Stollings JL, Kotfis K, Chanques G, Pun BT, Pandharipande PP, Ely EW. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med. 2021;47(10):1089–103. https://doi.org/10.1007/s00134-021-06503-1.
Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753–62. https://doi.org/10.1001/jama.291.14.1753.
Gitti N, Renzi S, Marchesi M, Bertoni M, Lobo FA, Rasulo FA, et al. Seeking the light in intensive care unit sedation: the optimal sedation strategy for critically ill patients. Front Med (Lausanne). 2022;9:901343. https://doi.org/10.3389/fmed.2022.901343.
Duprey MS, Dijkstra-Kersten SMA, Zaal IJ, Briesacher BA, Saczynski JS, Griffith JL, et al. Opioid use increases the risk of delirium in critically ill adults independently of pain. Am J Respir Crit Care Med. 2021;204(5):566–72. https://doi.org/10.1164/rccm.202010-3794OC.
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009;301(5):489–99. https://doi.org/10.1001/jama.2009.56.
Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46(9):e825–73. https://doi.org/10.1097/ccm.0000000000003299.
Lewis K, Alshamsi F, Carayannopoulos KL, Granholm A, Piticaru J, Al Duhailib Z, et al. Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials. Intensive Care Med. 2022;48(7):811–40. https://doi.org/10.1007/s00134-022-06712-2.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012;307(11):1151–60. https://doi.org/10.1001/jama.2012.304.
Huang Z, Liu N, Hu S, Ju X, Xu S, Wang S. Effect of dexmedetomidine and two different doses of esketamine combined infusion on the quality of recovery in patients undergoing modified radical mastectomy for breast cancer – a randomised controlled study. Drug Des Devel Ther. 2023;17:2613–21. https://doi.org/10.2147/dddt.S422896.
Kim JG, Lee HB, Jeon SB. Combination of dexmedetomidine and ketamine for magnetic resonance imaging sedation. Front Neurol. 2019;10:416. https://doi.org/10.3389/fneur.2019.00416.
Frestadius A, Grehn F, Kildal M, Huss F, Fredén F. Intranasal dexmedetomidine and rectal ketamine for young children undergoing burn wound procedures. Burns. 2022;48(6):1445–51. https://doi.org/10.1016/j.burns.2021.08.005.
Lin Z, Li S, Zhou Y, Lu X, Yang B, Yu Z, et al. A comparative study of esketamine-dexmedetomidine and sufentanil-dexmedetomidine for sedation and analgesia in lung tumor percutaneous radiofrequency ablation (PRFA): a randomized double-blind clinical trial. BMC Anesthesiol. 2023;23(1):304. https://doi.org/10.1186/s12871-023-02266-y.
Lian X, Lin Y, Luo T, Jing Y, Yuan H, Guo Y. Efficacy and safety of esketamine for sedation among patients undergoing gastrointestinal endoscopy: a systematic review and meta-analysis. BMC Anesthesiol. 2023;23(1):204. https://doi.org/10.1186/s12871-023-02167-0.
Trimmel H, Helbok R, Staudinger T, Jaksch W, Messerer B, Schöchl H, et al. S(+)-ketamine : current trends in emergency and intensive care medicine. Wien Klin Wochenschr. 2018;130(9–10):356–66. https://doi.org/10.1007/s00508-017-1299-3.
Lu Y, Yin G, Jin C, Gu K, Bao D, Xu W, et al. The application value of esketamine and dexmedetomidine in preventing postoperative delirium and hyperalgesia in elderly patients with thoracic anesthesia. Altern Ther Health Med. 2024;30(3):80–5.
Ma J, Wang F, Wang J, Wang P, Dou X, Yao S, et al. The effect of low-dose esketamine on postoperative neurocognitive dysfunction in elderly patients undergoing general anesthesia for gastrointestinal tumors: a randomized controlled trial. Drug Des Devel Ther. 2023;17:1945–57. https://doi.org/10.2147/dddt.S406568.
Chen Y, Ru F, Ye Q, Wu X, Hu X, Zhang Y, et al. Effect of S-ketamine administered at the end of anesthesia on emergence delirium in preschool children undergoing tonsillectomy and/or adenoidectomy. Front Pharmacol. 2023;14:1044558. https://doi.org/10.3389/fphar.2023.1044558.
Wang C, Wu Y, Yue P, Ely EW, Huang J, Yang X, et al. Delirium assessment using Confusion Assessment Method for the Intensive Care Unit in Chinese critically ill patients. J Crit Care. 2013;28(3):223–9. https://doi.org/10.1016/j.jcrc.2012.10.004.
Inouye SK, Kosar CM, Tommet D, Schmitt EM, Puelle MR, Saczynski JS, et al. The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014;160(8):526–33. https://doi.org/10.7326/m13-1927.
Lu X, Tang L, Lan H, Li C, Lin H. A comparison of intranasal dexmedetomidine, esketamine or a dexmedetomidine-esketamine combination for induction of anaesthesia in children: a randomized controlled double-blind trial. Front Pharmacol. 2021;12:808930. https://doi.org/10.3389/fphar.2021.808930.
van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, et al. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ. 2012;344:e420. https://doi.org/10.1136/bmj.e420.
Burry LD, Cheng W, Williamson DR, Adhikari NK, Egerod I, Kanji S, et al. Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis. Intensive Care Med. 2021;47(9):943–60. https://doi.org/10.1007/s00134-021-06490-3.
Ng KT, Shubash CJ, Chong JS. The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis. Anaesthesia. 2019;74(3):380–92. https://doi.org/10.1111/anae.14472.
Kim JY, Kim KN, Kim DW, Lim HJ, Lee BS. Effects of dexmedetomidine sedation for magnetic resonance imaging in children: a systematic review and meta-analysis. J Anesth. 2021;35(4):525–35. https://doi.org/10.1007/s00540-021-02946-4.
Zhang Y, Cui F, Ma JH, Wang DX. Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial. Br J Anaesth. 2023;131(2):385–96. https://doi.org/10.1016/j.bja.2023.05.001.
Xu LL, Wang C, Deng CM, Dai SB, Zhou Q, Peng YB, et al. Efficacy and safety of esketamine for supplemental analgesia during elective cesarean delivery: a randomized clinical trial. JAMA Netw Open. 2023;6(4):e239321. https://doi.org/10.1001/jamanetworkopen.2023.9321.
Gao Y, Deng X, Yuan H, Leng Y, Zhang T, Xu X, et al. Patient-controlled intravenous analgesia with combination of dexmedetomidine and sufentanil on patients after abdominal operation: a prospective, randomized, controlled, blinded, multicenter clinical study. Clin J Pain. 2018;34(2):155–61. https://doi.org/10.1097/ajp.0000000000000527.
Colvin LA, Bull F, Hales TG. Perioperative opioid analgesia-when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet. 2019;393(10180):1558–68. https://doi.org/10.1016/s0140-6736(19)30430-1.
Guo X, Xue Y, Ji W, Liang J, Qingshi Z. Effects of administration of α(2) adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund’s adjuvant in rats. Mol Pain. 2022;18:17448069221107810. https://doi.org/10.1177/17448069221107810.