Highly Infectious Avian Flu Is Inactive in Pasteurized Milk Products

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In March 2024, dairy cows in Texas were found to be infected with highly pathogenic avian influenza A (H5N1), in the first known case of the virus spreading to cattle. Since then, H5N1 has been found in about 200 animals—and 3 people—across 12 states, according to the Centers for Disease Control and Prevention (CDC). The virus was soon detected in raw milk, leading researchers to investigate whether dairy products pose a risk to consumers. 
 
“How far is the virus getting through?” asked Erica Spackman, Ph.D., a virologist at the U.S. Department of Agriculture (USDA) in Athens, Ga. To find out, she and her collaborators tested nearly 300 milk products from 132 processors. 
 
The researchers found no infectious virus in the samples, Spackman and her collaborators report this week in the Journal of Virology, a journal of the American Society for Microbiology. “Milk is safe,” she said. “Just like bacterial pathogens that occur in milk, or other viruses that could occur in milk, the sanitation processes that are in place are getting rid of the pathogens.”
 
The milk processing pipeline includes multiple layers of protection, Spackman said. Microbiological surveillance of milk products can identify pathogens, and milk from cows with mastitis or other disease conditions does not enter the food supply. Finally, heating during the pasteurization process can destroy H5N1 and other, more common bacterial pathogens. 
 
Avian influenza (bird flu) primarily infects and spreads among migratory birds and can be transmitted to domestic poultry, but the virus has been detected in other animals as well. Recently, those have included cats, dogs and juvenile goats, as well as a polar bear in Alaska and elephant and fur seals in the Antarctic. However, the discovery of H5N1 on dairy farms in March was a surprise—the virus had never been found in dairy cattle before.
 

Soon after the discovery, diagnostic testing revealed that an infectious form of the virus was present in raw milk, suggesting the virus passes from cow to milk. That finding led the U.S. Food and Drug Administration and the USDA to investigate whether pasteurization effectively eliminated risks posed to consumers. Between April 18 and April 22, 2024, researchers used real-time PCR to analyze 297 samples of pasteurized retail milk products, including 23 types of products, collected from 17 states. 
 
“We did a viability assay to detect live virus and went as sensitive as we could to get even the least little bit of virus, but couldn’t detect anything,” Spackman said. Using PCR, the researchers did identify viral genetic material in 20% of samples. “It looks like the virus is just totally inactivated,” she said.
 
Spackman said the new findings “give us reassurance that what we have been doing—pasteurization—is keeping us safe from what we don’t know about.” 

Reference: Spackman E, Jones DR, McCoig AM, Colonius TJ, Goraichuk IV, Suarez DL. Characterization of highly pathogenic avian influenza virus in retail dairy products in the US. J Virol. 2024:e00881-24. doi: 10.1128/jvi.00881-24

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