Lizzo reacts to South Park joke about her in episode about Ozempic

Lizzo says being referenced in a South Park episode is her “worst fear” – and shared her reaction to the joke in real time on social media. 

The popstar was namechecked in the latest episode of the long-running cartoon, The End of Obesity, which parodies the popularity of weight-loss drugs such as Ozempic and Mounjaro.

Lizzo shared a clip from the show alongside her reaction to the scene – opening the video by saying: “I’m so scared.”

The clip features a conversation between Sharon and Sheila, the mothers of Stan and Kyle.

Sharon says her doctor wouldn’t prescribe her any weight-loss injections because she doesn’t have diabetes, but says “there’s a whole new obesity drug for those of us who can’t afford Ozempic and Mounjaro”.

“I controlled all my cravings to be thinner with ‘Lizzo’,” she says – prompting the singer to clap her hand over her mouth.

The clip then goes into a fake advert for “Lizzo”, which says the drug makes users “feel good about [their] weight,” claiming that 70% of those who took it “no longer cared how much they weighed”.

“Lizzo helps you eat everything you want and keep physical activity to a minimum,” the voiceover says.

“Some patients report constipation while listening to Lizzo. Stop listening to Lizzo if you experience suicidal thoughts.”

At the end of the ad, the voiceover asks: “Are you living with concerns of obesity?”

Sharon turns to the camera and says: “Ask about the power of not giving a f*** – with Lizzo” – as the singer looks on wide-eyed and open-mouthed.

“That’s crazy!”, Lizzo says as the clip finishes.

“I really showed the world how to love yourself and not give a f***, to the point where these men [South Park creators Trey Parker and Matt Stone] in Colorado know who the f*** I am, and put it on their cartoon that’s been around for 25 years,” she says.

“I’m really that bitch, and I show you how to not give a f*** and I’ll keep showing you how to not give a f***.”

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Lizzo is known for championing body positivity and is no stranger to fat shaming.

She has been credited with changing the narrative around plus-size women, calling out sizeist behaviour and refusing to conform to industry stereotypes.

However, last year the singer faced claims she is guilty of weight shaming and sexual harassment – allegations she denies – with three of her former singers bringing a lawsuit against her.