New Study Sheds More Light on Genetics of Coffee Consumption | Sci.News

Coffee is one of the most widely consumed beverages. In new research, scientists from the University of California, San Diego and elsewhere performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants. They examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then compared their results to the largest available GWAS of coffee intake from the UK Biobank.

“We collected genetic data as well as self-reported coffee-consumption numbers to assemble a GWAS,” said lead author Dr. Hayley Thorpe, a researcher at Western University and the University of Guelph.

“The idea was to make connections between the genes that were known to be associated with coffee consumption and the traits or conditions related to health.”

“We used these data to identify regions on the genome associated with whether somebody is more or less likely to consume coffee.”

“And then identify the genes and biology that could underlie coffee intake.”

“Most people are surprised that there is a genetic influence on coffee consumption,” said co-author Dr. Abraham Palmer, a researcher at the University of California, San Diego.

“We had good reason to suspect from earlier papers that there were genes that influence how much coffee someone consumes.”

“And so, we weren’t surprised to find that in both of the cohorts we examined there was statistical evidence that this is a heritable trait.”

“In other words, the particular gene variants that you inherit from your parents influence how much coffee you’re likely to consume.”

“The genetic influence on coffee consumption was the first of two questions we wanted to address,” said senior author Dr. Sandra Sanchez-Roige, a researcher at the University of California, San Diego.

“The second is something that coffee lovers are really keen on learning. Is drinking coffee good or bad? Is it associated with positive health outcomes or not?”

The group’s genome-wide association study of 130,153 U.S.-based 23andMe research participants was compared with a similar UK Biobank database of 334,649 Britons, revealing consistent positive genetic associations between coffee and harmful health outcomes such as obesity and substance use.

A positive genetic association is a connection between a specific gene variant (genotype) and a specific condition (phenotype).

Conversely, a negative genetic association is an apparent protective quality discouraging the development of a condition.

The findings get more complicated when it comes to psychiatric conditions.

“Look at the genetics of anxiety, for instance, or bipolar and depression: in the 23andMe dataset, they tend to be positively genetically correlated with coffee intake genetics,” Dr. Thorpe said.

“But then, in the UK Biobank, you see the opposite pattern, where they’re negatively genetically correlated. This is not what we expected.”

“There were other instances in which the 23andMe set didn’t align with the UK Biobank, but the greatest disagreement was in psychiatric conditions.”

“It’s common to combine similar datasets in this field to increase study power. This information paints a fairly clear picture that combining these two datasets was really not a wise idea. And we didn’t end up doing that.”

“Melding the databases might mask effects, leading researchers toward incorrect conclusions — or even cancelling each other out.”

“We have some ideas about how the differences in results arose. To begin with, there was an apples-and-oranges aspect to the surveys,” Dr. Sanchez-Roige said.

“For instance, the 23andMe survey asked, ‘How many 5-ounce (cup-sized) servings of caffeinated coffee do you consume each day?’ Compare it to the UK Biobank’s ‘How many cups of coffee do you drink each day? (Include decaffeinated coffee)’.”

“Beyond serving size and the caffeinated/decaf divide, the surveys made no accommodation for the various ways coffee is served.”

“We know that in the U.K., they have generally higher preference for instant coffee, whereas ground coffee is more preferred in the U.S.,” Dr. Thorpe said.

“And then there’s the frappuccinos — the American trend of taking coffee loaded with sugary additives,” Dr. Sanchez-Roige added.

“There are other caffeinated drinks and especially in the context of the UK Biobank, tea, none of which were included in the GWAS, which addressed only coffee,” Dr. Palmer said.

“The GWAS demonstrates the relationship between genotype and phenotype is more different than the relationship between coffee and tea.”

“Genetics influences lots of things. For instance, it influences how tall you might be.”

“And those kinds of things probably would play out very similarly, whether you lived in the U.S. or the U.K. But coffee is a decision that people make.”

“Coffee comes in a variety of forms, from instant to frappuccino, and is consumed amid cultural norms that differ from place to place,” Dr. Sanchez-Roige said.

“A person with a given genotype might end up having quite a different phenotype living in the U.K. versus the U.S.”

“And that’s really what the data are telling us. Because unlike height, where your behavior doesn’t really have much to do with it, your behavior and the choices you’re making in your environment play out in various ways. So the interaction between genotype and environment complicates the picture.”

The team’s paper was published in the journal Neuropsychopharmacology.

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H.H.A. Thorpe et al. Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations. Neuropsychopharmacol, published online April 17, 2024; doi: 10.1038/s41386-024-01870-x